Hyderabad [Telangana], April 27: Dr. D. Srinivas Reddy, Chairman, and CEO of Optimus Pharma announced that they have filed for seeking emergency approval for Phase 3 Clinical Trial from the Drugs Controller General of India. Once the approval is granted for Phase 3 Clinical Trial, we would be extensively accelerating the manufacturing of our in-house developed generic version of Molnupiravir for making it available in the Indian market as soon as possible. Optimus Pharma is committed to halting the pandemic across the nation and ensuring immediate relief to all those who have been infected with the highly virulent SARS-CoV-2.
Optimus Pharma is pleased to announce the development of oral Molnupiravir on the fast lane. Optimus Pharma is becoming a key player in the fight against the COVID-19 pandemic in India has already achieved very high production levels of Favipiravir one of our flagship drugs for COVID-19 infection. In a bid to develop and diversify our anti-viral portfolio especially against SARS-CoV-2, we are here with yet another promising drug to compensate for the lack of antiviral drugs in the market further diversifying our antivirals portfolio. In hindsight of the raging second wave, Molnupiravir has been developed for non-hospitalized mild to moderate infections of SARS-CoV-2. Optimus Pharma is aggressively pushing for achieving scalability for 800mg dose of the drug.
Our available pre-clinical data on Molnupiravir already demonstrated that there were no adverse clinical signs and mortality observed in any of the treatment groups, as compared to the control group of animals with high efficacy and thereby effectively neutralizing virulence of the SARS-CoV-2 virus in the test group as compared to control group.
The drug is effective against a variety of viruses that use an RNA-dependent RNA polymerase (RdRp), as is the case with SARS-CoV-2 which is directly responsible for the transcription of Viral m-RNA of the virus in the infected subject. Early in vitro tests of Molnupiravir on SARS-CoV-2 revealed a steady decrease in virus output that was proportional to the dose of Molnupiravir used. Since the RdRp of SARS-CoV-2 and SARS-CoV, which the drug was designed to treat, has 99.1% nucleotide similarity hence, this was possible. Repeated drug exposure quickly neutralized virus populations, ensuring that none of the random mutations mediate drug resistance. As the drug is introduced in higher amounts, the titer levels and genome output of SARS-CoV-2 decrease exponentially.
It has been observed that Molnupiravir is only marginally successful in preventing extreme SARS-CoV-2 infection that is severe cases of the infection. This might have been the reason for their withdrawal and continue the trial only with non-hospitalized patients that are subjects with mild to moderate infection. We aim to do the same and establish its efficacy in the same treatment group.
Phase 2 Clinical Trial study on enrolled 202 non-hospitalized adults is already made available by the innovator of the molecule. Virological analysis was characterized by a marked decrease in positive viral culture in subjects who received Molnupiravir (all doses) relative to placebo – at day 5: 0% (0/47) for Molnupiravir and 24% (6/25) for placebo. Furthermore, the secondary objective for a faster decrease in infectious virus among people with early COVID-19 who were treated with Molnupiravir is encouraging and Phase 3 Clinical Trials are warranted for checking the efficacy of the molecule across demographics, particularly as the SARS-CoV-2 virus continues to spread and evolve globally.
Unlike the current drugs being administered intravenously, Molnupiravir is administered orally. This makes it a promising drug to halt the disease progression in the early stages as well as mount a powerful response against moderate infection levels. The fact that this molecule can be consumed as an orally administered drug in the form of an 800mg capsule renders a maverick advantage to achieve scalability in terms of upscaling from gm scale to multi-ton levels in a short time frame, thereby ensuring availability in the Indian market at a comparatively exponential scale. In vitro assays indicate that it is significantly more effective than the drugs being used currently, and the safety profile appears to be satisfactory.
I pay a visit day-to-day some websites and sites to read content, however
this blog offers quality based content.
Attractive component to content. I just stumbled upon your weblog and in accession capital to say that I get actually enjoyed account your weblog posts.
Anyway I’ll be subscribing to your augment and even I success you access consistently rapidly.
Asking questions are really nice thing if you are not understanding something completely,
but this piece of writing presents good understanding even.
Hi there to all, it’s really a pleasant for me to pay a visit this site, it contains useful Information.
Very nice post. I just stumbled upon your blog and wanted
to say that I have really loved surfing around your weblog posts.
In any case I’ll be subscribing in your feed and I am hoping you write once more soon!
I’m very pleased to uncover this website. I want to to thank you for your time for this
particularly wonderful read!! I definitely appreciated every bit of it and I have you book marked to see
new information on your site.
An outstanding share! I have just forwarded this onto a co-worker who was conducting a little homework on this.
And he actually ordered me lunch due to the fact that I discovered it for him…
lol. So allow me to reword this…. Thanks for the meal!!
But yeah, thanks for spending the time to talk about this matter here on your website.
Heya i’m for the first time here. I came across this board
and I find It really useful & it helped me out a lot.
I hope to give something back and help others like you aided me.
I couldn’t refrain from commenting. Well written!
Hey there! Would you mind if I share your blog with
my facebook group? There’s a lot of people that I think would really appreciate your content.
Please let me know. Thank you
I’m not sure exactly why but this blog is loading very
slow for me. Is anyone else having this issue or is it a issue on my end?
I’ll check back later and see if the problem still exists.
Hey! I just wanted to ask if you ever have any trouble with
hackers? My last blog (wordpress) was hacked and I ended up losing several weeks of hard work due to no data backup.
Do you have any solutions to prevent hackers?
Hello there! This is my first comment here so I just wanted to give a
quick shout out and tell you I truly enjoy reading your posts.
Can you recommend any other blogs/websites/forums that cover
the same topics? Thanks a lot!
Wow, this article is fastidious, my sister is analyzing such things, therefore I am going
to convey her.
levaquin 500mg price buy levofloxacin 500mg pills
I don’t even know how I ended up here, but I thought
this post was great. I do not know who you are but definitely you are going to a famous blogger if
you aren’t already 😉 Cheers!
Feel free to surf to my web site: coupon
order tadalis generic order tadalafil online cheap voltaren online
oral imdur 20mg order micardis 20mg without prescription order telmisartan sale
buy lasix 40mg online generic doxycycline hydroxychloroquine order online
tadalafil 20mg brand order inderal for sale buy plavix 150mg generic
buy tamsulosin 0.2mg sale ondansetron medication aldactone price
cost tadalafil buy acillin online ciprofloxacin pills
zocor 20mg sale oral valacyclovir 1000mg finasteride 5mg oral
buy flagyl 200mg clavulanate generic purchase bactrim pill
fluconazole over the counter fluconazole 200mg for sale sildenafil 20mg
buy keflex 125mg online cost keflex 500mg erythromycin 500mg generic
cheap tadalafil for sale cialis 40mg oral brand name viagra
real viagra pills overnight delivery viagra viagra cialis
generic cefuroxime 250mg bimatoprost drug robaxin 500mg us
play slots online blackjack online money cialis 5mg sale
generic trazodone 50mg buy generic sildenafil sildenafil 50mg pills
mba essay service brand stromectol ivermectin 3mg over counter
sildalis canada viagra sildenafil 150mg purchase lamictal pills
deltasone 40mg price cheap amoxicillin generic amoxil oral
rx pharmacy online viagra buy sildenafil without prescription tadalafil 20mg canada
legitimate online slots for money hollywood casino online cialis 20mg pills
buy azithromycin 250mg zithromax 250mg usa order gabapentin 100mg
doubleu casino online casino modafinil 200mg cheap purchase modafinil online cheap
furosemide order order doxycycline online buy plaquenil 400mg online
sildenafil 50mg brand rhinocort order online purchase budesonide pills
buy prednisone 20mg generic mebendazole 100mg uk vermox 100mg us
tretinoin order tadalis drug avana online order
tadalafil pills buy tadalafil 10mg generic indomethacin 75mg without prescription